abstract：BACKGROUND:Dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) occasionally resemble each other histologically but differ in histogenesis and biological behavior. This study sought to determine if these lesions can be differentiated by the quantity or quality of expression of cyclooxygenase-2 (COX-2), an enz...

journal_title：Journal of cutaneous pathology

authors： Adler N,Tsabari C,Sulkes J,Ad-El D,Feinmesser M

更新日期：2008-06-01 00:00:00

abstract：:We report a case of a 68-year-old man with cutaneous leiomyosarcoma of the penis. Leiomyosarcoma of the penis is an extremely rare neoplasm that usually presents in middle to old age, and to our knowledge only approximately 30 cases have been reported in the literature to date. This is an important diagnosis in the di...

journal_title：Journal of cutaneous pathology

authors： Cibull TL,Thomas AB,Badve S,Billings SD

更新日期：2008-06-01 00:00:00

abstract：:A 60-year-old female and a 59-year-old male each presented with a solitary circumscribed patch of depressed skin of the right thenar palm and right sole, respectively. Both lesions were present for approximately 30 years without a history of trauma or other inciting incident. Histologically, the lesions showed a well-...

journal_title：Journal of cutaneous pathology

authors： Barry CI,Glusac EJ,Kashgarian M,Gwin K,McNiff JM

更新日期：2008-05-01 00:00:00

abstract：:Oral mucosal melanoma (OMM) is an extremely rare malignancy, accounting for < 0.5% of all melanomas and all oral malignancies. The rarity of OMM, the heterogeneity in clinical and histopathologic appearances, and the paucity of molecular and genetic studies to date have limited our knowledge of the etiopathogenesis of...

journal_title：Journal of cutaneous pathology

authors： Kumar SK,Shuler CF,Sedghizadeh PP,Kalmar JR

更新日期：2008-04-01 00:00:00

abstract：:While some unequivocally benign infiltrates are easy to distinguish from cutaneous T-cell lymphoma (CTCL), drug-associated lymphomatoid hypersensitivity reaction and cutaneous lesions of collagen vascular disease can show cytologic atypia, clonality and an immunophenotypic profile that closely simulates CTCL and cause...

journal_title：Journal of cutaneous pathology

authors： Plaza JA,Morrison C,Magro CM

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Src-family tyrosine kinases (SFKs) are important regulators of keratinocyte growth and differentiation. In a broad range of cell types, persistent activation of SFKs correlates with increased cell proliferation. In this study, we determined if SFK activity is increased in cutaneous neoplasia and psoriasis, c...

journal_title：Journal of cutaneous pathology

authors： Ayli EE,Li W,Brown TT,Witkiewicz A,Elenitsas R,Seykora JT

更新日期：2008-03-01 00:00:00

abstract：:We describe the case of a cutaneous symplastic leiomyoma in a 37-year-old woman who presented with a 4-year history of a painful slow growing lesion on the left upper arm. The lesion was excised and subjected to histological examination. A poorly circumscribed lesion was seen in the dermis composed of spindle shaped c...

journal_title：Journal of cutaneous pathology

authors： Usmani N,Merchant W,Yung A

更新日期：2008-03-01 00:00:00

abstract：:The term hemangioendothelioma has been used in recent years to name a heterogeneous group of vascular neoplasms, intermediate in both biological behavior and histopathologic appearance between benign tumors (hemangiomas) and frankly malignant tumors (angiosarcomas). Thus, within the spectrum of hemangioendothelioma ha...

journal_title：Journal of cutaneous pathology

authors： Requena L,Luis Díaz J,Manzarbeitia F,Carrillo R,Fernández-Herrera J,Kutzner H

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:The cell origin of dermatofibroma (DF) has not been clarified satisfactorily. This study was undertaken to assess the distribution of fibroblasts and the relationship between fibroblasts and other constituent cells in DF by 47-kDa heat-shock protein (HSP47), a cell marker for skin fibroblast. METHODS:Immuno...

journal_title：Journal of cutaneous pathology

authors： Kuroda K,Tajima S

更新日期：2008-01-01 00:00:00

abstract：:Dermatomyositis, a connective tissue disease syndrome where antibodies to the endothelium of the microvasculature of the skin, muscle and lung are implicated in lesional propagation, is characterized by photodistributed erythema, heliotrope rash, Gottron's papules, muscle weakness and interstitial pulmonary fibrosis. ...

journal_title：Journal of cutaneous pathology

authors： Magro CM,Schaefer JT,Waldman J,Knight D,Seilstad K,Hearne D

更新日期：2008-01-01 00:00:00

abstract：:A 31 year old Indian woman presented with bilateral axillary masses that became noticeable with the onset of puberty. The masses exhibited similar consistency to the adjacent normal breast tissue but lacked an associated nipple complex. The clinical impression was lipoma; however, mammography, ultrasonography and skin...

journal_title：Journal of cutaneous pathology

authors： Ghosn SH,Khatri KA,Bhawan J

更新日期：2007-12-01 00:00:00

abstract：:Many melanocytic nevi contain areas similar to nerve sheath tumors (NST) and NSTs with melanin have been described. There are some NSTs with at least partial intraneural location, including neurofibromas, plexiform neurofibromas, granular cell tumors and the recently described, dendritic cell neurofibroma with pseudor...

journal_title：Journal of cutaneous pathology

authors： Weinreb I,Labonte S,Goli H,Chetty R,Ghazarian D

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Pyoderma gangrenosum (PG) is a non-infectious, autoimmune, chronic ulcer of the skin, often co-existing with inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) have been implicated as mediators of tissue destruction in chronic cutaneous and intestinal wounds. METHODS:Twenty-four skin biopsie...

journal_title：Journal of cutaneous pathology

authors： Bister V,Mäkitalo L,Jeskanen L,Saarialho-Kere U

更新日期：2007-12-01 00:00:00

abstract：:Genital leiomyoma in men include those superficial leiomyomas arising in the scrotum and the areola. They are unusual neoplasms: few cases have been reported in the literature and they usually escape clinical diagnosis. Three cases of male genital leiomyomas are reported: two in the scrotum and one in the areola. They...

journal_title：Journal of cutaneous pathology

authors： Suárez-Peñaranda JM,Vieites B,Evgenyeva E,Vázquez-Veiga H,Forteza J

更新日期：2007-12-01 00:00:00

abstract：AIM:Adnexal tumors with divergent lines of differentiation are uncommon. Herein, I report a hamartoma of the eyelid with follicular, sebaceous and apocrine differentiation that exhibited prominent melanin pigmentation. METHODS:A 63-year-old white woman had a nodule present on her left upper eyelid for 15 years. The no...

journal_title：Journal of cutaneous pathology

authors： Proia AD

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:The migration of circulating monocytes into the dermis is considered to be essential for both the initiation and the progression of xanthoma. The contribution of vascular endothelial cells to the migration process is unclear. METHODS:Twenty cases of xanthelasma and six cases of tuberous xanthoma lesions wer...

journal_title：Journal of cutaneous pathology

authors： Matsumoto M,Kunimitsu S,Wada K,Ikeda M,Yokogawa M,Keyama A,Kodama H

更新日期：2007-10-01 00:00:00

abstract：AIM:In the absence of mites, the histologic diagnosis of human scabies can be difficult. Scabies can mimic a variety of inflammatory and lymphoproliferative disorders. It is under-recognized that scabies can also mimic Langerhans cell histiocytosis. METHODS:Sixteen examples of scabies were reviewed histologically and ...

journal_title：Journal of cutaneous pathology

authors： Bhattacharjee P,Glusac EJ

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:The present study evaluates the signal transducer and activator of transcription-3 (STAT-3) expression and activation in actinic cheilitis (AC) and the relationship of this protein with the degree of epithelial dysplasia. METHODS:Twenty-five cases of AC were analyzed. Normal lip mucosa was used as a control...

journal_title：Journal of cutaneous pathology

authors： Cury PR,Furuse C,de Araújo NS,de Araújo VC

更新日期：2007-08-01 00:00:00

abstract：:Mycosis fungoides (MF) is a rare type of non-Hodgkin's lymphoma affecting the skin. Because MF develops slowly over several years and may have a variety of clinical presentations, including itchy patches, plaques or tumors that may be confused with common benign conditions such as eczema and psoriasis, the disease pre...

journal_title：Journal of cutaneous pathology

authors： Reddy K,Bhawan J

更新日期：2007-07-01 00:00:00

abstract：:Although CD1a+ dendritic cells (DC) in cutaneous T-cell lymphomas (CTCL) have been well documented, the presence of large numbers of DC within lymphoid infiltrates can pose a diagnostic difficulty. We present a case of a 70-year-old man with a 3-year history of recurrent red papules and plaques on the extremities and ...

journal_title：Journal of cutaneous pathology

authors： Jokinen CH,Wolgamot GM,Wood BL,Olerud J,Argenyi ZB

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Nickel can induce cellular and nuclear damages responsible for chronic diseases, like allergic contact dermatitis (ACD). We previously showed that matrix metalloproteinase-2 (MMP-2) gene expression was induced by nickel in nontumorigenic human keratinocytes cell line (HaCat). OBJECTIVE:To investigate the si...

journal_title：Journal of cutaneous pathology

authors： Perfetto B,Lamberti M,Giuliano MT,Canozo N,Cammarota M,Baroni A

更新日期：2007-06-01 00:00:00

abstract：:Mucinous cutaneous adnexal tumors are an uncommon occurrence. We describe three cases of mucinous hidradenoma characterized by diffuse and prominent mucinous cell proliferation and discuss the relevant literature. The patients (two men and one woman) ranged in age from 32 to 72 years. The lesions were completely excis...

journal_title：Journal of cutaneous pathology

authors： Goh SG,Carr R,Dayrit JF,Calonje E

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Nestin is one of the intermediate filaments that are expressed in proliferating neural progenitor cells during development of the central nervous system (CNS) and peripheral nervous system. Postnatal re-expression of the protein occurs mainly under pathological conditions, including injury and neoplasia. In ...

journal_title：Journal of cutaneous pathology

authors： Brychtova S,Fiuraskova M,Hlobilková A,Brychta T,Hirnak J

更新日期：2007-05-01 00:00:00

abstract：:A case of an osteogenic desmoplastic melanoma occurring on the sole of the foot of a 60-year-old African American man is described. The tumor measured 4.8 cm in greatest dimension, invaded to a thickness of 2.2 cm and metastasized to four of ten inguinal lymph nodes. The majority of the tumor had a classic desmoplasti...

journal_title：Journal of cutaneous pathology

authors： Emanuel PO,Idrees MT,Leytin A,Kwon EJ,Phelps RG

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:It is not clear why melanocyte disappearance occurs without fibrotic evolution in halo nevus and with fibrotic evolution in regressing melanoma. METHODS:Six halo nevi, seven regressing primary melanomas, and seven primary melanoma (PM) without regression were studied using immunohistochemistry for the pheno...

journal_title：Journal of cutaneous pathology

authors： Moretti S,Spallanzani A,Pinzi C,Prignano F,Fabbri P

更新日期：2007-04-01 00:00:00

abstract：:Epidermolytic hyperkeratosis (EH) is a well-described histopathologic pattern characteristic of bullous congenital ichthyosiform erythroderma, an autosomal dominant genodermatosis. It is also noted in cutaneous disorders where mosaicism leads to containment of the clinical and histopathologic changes. EH has been obse...

journal_title：Journal of cutaneous pathology

authors： Steele CL,Shea CR,Petronic-Rosic V

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Psoriasis vulgaris is a common chronic inflammatory dermatosis. Disorders in keratinocyte proliferation, differentiation, inflammation and immune dysregulation are the major factors implicated in the pathogenesis of psoriasis vulgaris. METHODS:The study was performed in skin specimens of 25 patients with ps...

journal_title：Journal of cutaneous pathology

authors： Doger FK,Dikicioglu E,Ergin F,Unal E,Sendur N,Uslu M

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:BMI-1 is involved in the maintenance of stem cells and functions as an oncogene in both lymphomas and solid carcinomas, acting by downregulation of p16ink4a. We have investigated the expression profile of BMI-1 in normal and inflamed skin as well as in basal cell carcinomas (BCCs) and squamous cell carcinoma...

journal_title：Journal of cutaneous pathology

authors： Reinisch CM,Uthman A,Erovic BM,Pammer J

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:The Wnt-signaling pathway, involving beta-catenin, apc, and axin, plays a critical role in numerous developmental events. Alterations in the Wnt-signaling pathway have been detected in a wide variety of neoplasms. However, similar aberrations have not been described in Merkel cell carcinoma (MCC). The aim of...

journal_title：Journal of cutaneous pathology

authors： Liu S,Daa T,Kashima K,Kondoh Y,Yokoyama S

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Glial cell line-derived neurotrophic factor (GDNF) and a related family member, neurturin (NTN), as well as their cognate receptors (GDNF receptors, GFRalpha-1 and GFRalpha-2, respectively) are involved in nervous system development and murine hair cycle control. To date, their expression in human scalp skin...

journal_title：Journal of cutaneous pathology

authors： Adly MA,Assaf HA,Hussein MR,Paus R

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Rare cases of a non-bullous neutrophilic dermatosis occurring in patients with lupus erythematosus (LE) have been reported, often as the presenting manifestation of the disease. METHODS:We reviewed hematoxylin and eosin-stained slides and obtained clinical information from four additional patients, two of w...

journal_title：Journal of cutaneous pathology

authors： Gleason BC,Zembowicz A,Granter SR

更新日期：2006-11-01 00:00:00

abstract：AIMS:The differential diagnosis of acral keratoses is broad. Encompassing a variety of infectious, heritable and degenerative disorders, emphasis upon the clinical setting and histologic subtlety are often required to arrive at the correct diagnosis. Herein, we report on a series of adult patients who presented with ag...

journal_title：Journal of cutaneous pathology

authors： Saeed S,Sagatys E,Morgan MB

更新日期：2006-10-01 00:00:00

abstract：:We report the case of a 51-year-old man with an asymptomatic indurated plaque on the chest wall that was surgically excised and submitted for histopathological examination. Microscopically, the dermis was occupied by a neoplastic process with spindle-shaped cells arranged in longitudinal fascicles with cytologic atypi...

journal_title：Journal of cutaneous pathology

authors： Berzal-Cantalejo F,Sabater-Marco V,Pérez-Vallés A,Martorell-Cebollada M

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The Fli-1 transcription factor functions in cellular proliferation and tumorigenesis. Its role in various neoplasms and its presence in lymphocytes suggest a link between Fli-1 dysregulation and the pathogenesis of mycosis fungoides (MF). In this study, we further elucidate this possible link. METHODS:Secti...

journal_title：Journal of cutaneous pathology

authors： Quick CM,Smoller BR,Hiatt KM

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Nerve growth factor (NGF) and its high-affinity receptor, tyrosine kinase A (TrkA), are members of the neurotrophin family. NGF-TrkA are involved in murine hair morphogenesis and cycling. To date, their expression in human hair follicle (HF) is unknown. In this investigation, we hypothesize that NGF-TrkA pro...

journal_title：Journal of cutaneous pathology

authors： Adly MA,Assaf HA,Nada EA,Soliman M,Hussein M

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:The diagnosis of tuberculoid leprosy is often difficult on hematoxylin and eosin (H&E) due to the absence of demonstrable nerve destruction. This study evaluates the utility of S-100 staining in identifying nerve fragmentation and differentiation of tuberculoid leprosy from other cutaneous granulomatous dise...

journal_title：Journal of cutaneous pathology

authors： Gupta SK,Nigam S,Mandal AK,Kumar V

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Histiocytic sarcoma is an exceedingly rare malignant neoplasm composed of cells with a monocyte/macrophage phenotype. In the current nosology of histiocytic neoplasms, histiocytic sarcoma is separate from indeterminate cell histiocytosis, a generally benign disorder characterized by proliferation of a CD1a+ ...

journal_title：Journal of cutaneous pathology

authors： Frater JL,Kling CW,Obadiah JM,Gardner LJ,Grosso LE,Resh B,Hurley MY

更新日期：2006-06-01 00:00:00

abstract：:Clear cell atypical fibroxanthoma (CCAFX) is a rare variant of atypical fibroxanthoma (AFX), a pleomorphic dermal tumour associated with a good prognosis. A 67-year-old man presented with a rapidly growing nodule on the ear, which had appeared over a 2-week period. Sections showed an ulcerated nodule composed of pleom...

journal_title：Journal of cutaneous pathology

authors： Murali R,Palfreeman S

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Pemphigoides gestationis (PG) is a blistering disorder of pregnancy caused by antibodies against basement membrane proteins. They are directed against the 180 kD bullous pemphigoid antigen (BPAg2), towards the epitopes within the NC 16A domain. There are many similarities between pemphigoid gestationis and b...

journal_title：Journal of cutaneous pathology

authors： Patton T,Plunkett RW,Beutner EH,Deng JS,Jukic DM

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:CD44 is a membrane glycoprotein and the major cell-surface receptor of hyaluronate (HA). Lack of CD44 expression in mouse epidermis leads to an abnormal HA accumulation in the dermis, indicating an important role of CD44 in local HA metabolism. Decrease of epidermal CD44 expression in patients of lichen scle...

journal_title：Journal of cutaneous pathology

authors： Kaya G,Augsburger E,Chavaz P,Saurat JH

更新日期：2006-03-01 00:00:00